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Furuta, Takuya; Maeyama, Takuya*; Ishikawa, Kenichi*; Fukunishi, Nobuhisa*; Fukasaku, Kazuaki*; Takagi, Shu*; Noda, Shigeho*; Himeno, Ryutaro*; Hayashi, Shinichiro*
Physics in Medicine & Biology, 60(16), p.6531 - 6546, 2015/08
Times Cited Count：19 Percentile：63.99(Engineering, Biomedical)Low reproducibility of dose distribution in inhomogeneous regions such as soft matter near bones is known with the simple dose analysis currently adopted in treatment planning of particle cancer therapy. Therefore a treatment planning system based on Monte Carlo simulation having better accuracy is highly desired. In order to assess the simulation accuracy of a Monte Carlo simulation code in situations closely related to medical application, we performed a comparison of dose distribution in a biological sample obtained by experiment and that by simulation. In particular, we irradiate a carbon beam on a biological sample composed of fresh chicken meat and bones, with a PAGAT gel dosimeter placed behind it, and compare the complex dose distribution in the gel dosimeter created by the beam passing through the inhomogeneous sample. Monte Carlo simulation using PHITS code was conducted by reconstructing the biological sample from its computed tomography images. The simulation accurately reproduced the experimental distal edge structure of the dose distribution with an accuracy under about 2 mm.
Nakagawa, Yoshinobu*; Pooh, K. H.*; Kobayashi, Toru*; Kageji, Teruyoshi*; Uyama, Shinichi*; Matsumura, Akira*; Kumada, Hiroaki
Journal of Neuro-Oncology, 62(1), p.87 - 99, 2003/04
Times Cited Count：126 Percentile：83.31(Oncology)Our concept of boron neutron capture therapy (BNCT) is selective destruction of tumor cells using the heavy-charged particles Yielded through 10B(n, alpha)7 Li reactions. In the analysis of side effects due to radiation, we included all the 159 patients treated between 1977 and 2001. With respect to the radiation dose (i.e. physical dose of boron n-alpha reaction), the new protocol prescribes a minimum tumor volume dose of 15Gy or, alternatively, a minimum target volume dose of 18Gy. The maximum vascular dose should not exceed 15Gy (physical dose of boron n-alpha reaction) and the total amount of gamma rays should remain below 10Gy, including core gamma rays from the reactor and capture gamma in brain tissue. The outcomes for 10 patients who were treated by the new protocol using a new mode composed of thermal and epithermal neutrons are reported.
Matsumura, Akira*; Yamamoto, Tetsuya*; Shibata, Yasushi*; Nakai, Kei*; Zhang, T.*; Akutsu, Hiroyoshi*; Matsushita, Akira*; Yasuda, Susumu*; Takano, Shingo*; Nose, Tadao*; et al.
Posuto Shikuensu Jidai Ni Okeru Noshuyo No Kenkyu To Chiryo, p.427 - 435, 2002/07
no abstracts in English
